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目的:探讨3.0T磁共振(MRI)高b值弥散加权成像(DWI)在前列腺癌诊断及分化程度评估中的应用价值。材料与方法:回顾性分析2015年1月至2017年6月经临床证实的23例前列腺癌(PCa)和21例前列腺增生(BPH)患者,采用GE3.0T超导型MRI扫描仪行常规序列及高b值DWI序列检查。分析b值分别为1000s/mm~2、2000s/mm~2时,PCa病灶与BPH表观扩散系数(ADC)值的变化趋势及有无统计学意义。将23例前列腺癌患者根据病理分化程度分为高分化组、中分化组和低分化组,分别测量各组病灶ADC值,观察分析不同分化程度组间病灶ADC值差异及有无统计学意义。结果:PCa病灶于b值为2000s/mm~2时较1000s/mm~2所测平均ADC值为低,两组差异有统计学意义(P<0.05);相同b值ADC伪彩图所测PCa病灶平均ADC值低于BPH,两组差异有统计学意义(P<0.05)。PCa病灶依据不同病理分化程度分组所测ADC值之间差异有统计学意义(P<0.05)。结论:高b值DWI及ADC值定量分析对于PCa的诊断、分化程度评估具有较高的临床应用价值。
Objective: To investigate the value of 3.0T magnetic resonance (MRI) high b value diffusion weighted imaging (DWI) in the diagnosis and differentiation of prostate cancer. Materials and Methods: A retrospective analysis of 23 clinically confirmed cases of prostate cancer (PCa) and 21 cases of BPH from January 2015 to June 2017 was performed using conventional GE3.0T MRI scanner High b value DWI sequence check. When the b value was 1000s / mm ~ 2, 2000s / mm ~ 2 respectively, the change trend of apparent diffusion coefficient (ADC) between PCa lesions and BPH was statistically significant. According to the degree of pathological differentiation, 23 patients with prostate cancer were divided into high differentiated group, moderately differentiated group and poorly differentiated group. The ADC value of each group was measured. The difference of ADC value between different groups was observed and statistically analyzed. Results: The average ADC value of PCa lesions at 2000s / mm ~ 2 was lower than 1000s / mm ~ 2, the difference was statistically significant (P <0.05) The average ADC value of PCa lesion was lower than that of BPH, the difference was statistically significant (P <0.05). PCa lesions according to the degree of differentiation of different groups were measured ADC values between the differences were statistically significant (P <0.05). Conclusion: Quantitative analysis of high b value DWI and ADC value has a high clinical value for the diagnosis and differentiation of PCa.