灶性硬化性肾小球肾炎(FSGN)是儿童期耐类固醇肾病综合征的主要病因。细胞毒类药物可使其缓解,但它可危害未来的生育力。环孢素以进行性肾功能衰竭为代价降低蛋白尿,药物性肾毒性可能起作用。因此现用FK506治疗FSGN。 1988年11月,一名19个月龄的健康男孩发生外周水肿。尿检显示蛋白4+,其他方面不明显。肌酸酐0.7mg/dl,血脲(BUN)16mg/dl,白蛋白1.8mg/dl,血清胆固醇411mg/dl Focal sclerosing glomerulonephritis (FSGN) is the leading cause of childhood steroid-induced nephrotic syndrome. Cytotoxic drugs can ease it, but it can harm future fertility. Cyclosporine reduces proteinuria at the expense of progressive renal failure, and pharmacologic nephrotoxicity may play a role. So now FK506 treatment of FSGN. In November 1988, a 19-month-old healthy boy developed peripheral edema. Urinalysis showed protein 4 +, the other is not obvious. Creatinine 0.7 mg / dl, blood urea (BUN) 16 mg / dl, albumin 1.8 mg / dl, serum cholesterol 411 mg / dl