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淋巴母细胞淋巴瘤(lymphoblastic lymphoma,LBL)是典型的高度侵袭型淋巴瘤,常伴随纵膈肿块、中枢神经系统(CNS)浸润及骨髓累及等症状,约占2%的非霍奇金淋巴瘤(non-Hodgkin lymphoma,NHL),其中85%~90%为T淋巴母细胞淋巴瘤(T-LBL),常见于青少年男性,诊断时中位年龄20岁。由于LBL与急性淋巴细胞白血病(ALL)在细胞形态学、免疫表型、基因型和细胞遗传学以及临床表现和预后等方面有相似之处,因此2008版WHO分类已将T-ALL与T-LBL归为同一种疾病,定义为定向于T细胞系的淋巴母细胞肿瘤。
Lymphoblastic lymphoma (LBL) is a typical highly invasive lymphoma, often accompanied by mediastinal mass, central nervous system (CNS) infiltration and bone marrow involvement and other symptoms, about 2% of non-Hodgkin’s lymphoma (NHL), of which 85% to 90% are T-lymphoblastic lymphoma (T-LBL), common in adolescent males at the median age of 20 years at diagnosis. Since LBL has similarities with acute lymphoblastic leukemia (ALL) in terms of cell morphology, immunophenotype, genotype and cytogenetics and clinical manifestations and prognosis, the 2008 WHO classification has combined T-ALL with T- LBLs belong to the same disease and are defined as lymphoblastic tumors that target the T cell line.