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应用非类固醇抗炎药物(NSAID)可造成严重的肾功能衰竭。55例微小病变型非炎性肾小球病(MCG)中有5例发病与服NSAD有关,5例均为女性,平均年龄57.4±11岁,从治疗前至出观蛋白尿应用NSAID6.9±6.4月,3例出现大量蛋白尿(11.3±10.2g/24小时)和水肿,另外2例是非肾病性蛋白尿(<3 g/24小时),2例发生急性肾功能不全。停服NSAID20.4±16天,全部病人达到完全缓解,80％病人在15天内缓解,2例急性肾功能不全者在停药后2周肾功能恢复正常,5例病
Application of non-steroidal anti-inflammatory drugs (NSAIDs) can cause severe renal failure. Five of the 55 patients with minimal-variant noninflammatory glomerulopathy (MCG) developed disease associated with NSAD, 5 of whom were women with a mean age of 57.4 ± 11 years. NSAID6.9 ± 6.4 months, 3 patients had massive proteinuria (11.3 ± 10.2g / 24 hours) and edema, the other 2 patients had non-nephrogenic proteinuria (<3 g / 24 hours) and 2 patients developed acute renal insufficiency. NSAIDs were discontinued for 20 ± 16 days, with complete remission in all patients, complete remission in 80% of patients within 15 days, normal renal function in 2 patients with acute renal insufficiency 2 weeks after discontinuation, and 5 patients