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对94例Ⅱ型糖尿病(NIDDM)患者的空腹血糖水平与胰岛素分泌功能进行对照性研究发现,口服葡萄糖耐量试验2h内平均胰岛素分泌量正常者52例(55.32%),降低者39例(41.5%),升高者3例(3.19%).葡萄糖负荷后胰岛素反应的不均一性与病人空腹血糖水平有关,随空腹血糖升高,平均胰岛素分泌量呈先升高后降低的变化趋势.从而提示,轻型或早期NIDDM患者的病理生理异常主要在于周围组织对胰岛素的抵抗,而胰岛素分泌功能保持相对正常;对于空腹血糖明显升高者,胰岛素分泌功能降低则较为突出,对这部分病人应给予胰岛素治疗.
The control study of fasting blood glucose and insulin secretion in 94 patients with type 2 diabetes mellitus (NIDDM) found that the mean insulin secretion in normal oral glucose tolerance test was 52 (55.32%) in 2h and 39 (41.5% ) And elevated in 3 cases (3.19%). The heterogeneity of insulin response after glucose load was related to the fasting blood glucose level of patients, with the fasting blood glucose rising, the average insulin secretion increased first and then decreased, suggesting that , Pathophysiological abnormalities in patients with mild or early NIDDM mainly due to the resistance of the surrounding tissue to insulin, and insulin secretion remains relatively normal; for those with significantly higher fasting blood glucose, insulin secretion is more prominent decline in this part of the patients should be given insulin treatment.