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目的评价坦索罗辛与威利坦联合应用治疗输尿管下段结石的疗效。方法回顾性分析我院96例输尿管下段结石患者,结石直径为0.2~0.8 cm。将患者分为3组,每组32例。对照组:坦索罗辛0.2 mg1次/d;试验1组:坦索罗辛0.2 mg 1次/d,加用威利坦40 mg 2次/d;试验2组:坦索罗辛0.2 mg 1次/d,加用威利坦80 mg 2次/d。治疗2周后评价治疗效果。结果治疗2周后,对照组、试验1组及试验2组的结石排出时间分别为(8.4±3.1)d、(6.6±2.7)d和(5.9±2.7)d,对照组与2个试验组比较差异有统计学意义(P<0.05),但2个试验组比较差异无统计学意义(P>0.05)。对照组、试验1组与试验2组排出结石的患者分别为22例(68.8%)、29例(90.6%)、30例(93.8%),2个试验组与对照组比较差异有统计学意义(P<0.05),而2个试验组间比较差异无统计学意义(P>0.05)。3组中因肾绞痛而使用止痛药物治疗者分别为6例(18.8%)、4例(12.5%)、3例(9.4%),差异无统计学意义(P>0.05)。结论联合应用坦索罗辛与威利坦治疗输尿管下段结石安全有效,能提高排石率,缩短排石时间。
Objective To evaluate the efficacy of tamsulosin combined with Willlitin in the treatment of lower ureteral calculi. Methods A retrospective analysis of 96 patients with lower ureteral calculi in patients with stones diameter of 0.2 ~ 0.8 cm. The patients were divided into 3 groups, 32 cases in each group. Control group: tamsulosin 0.2 mg once / d; Test group 1: tamsulosin 0.2 mg once / d plus Willitin 40 mg twice daily; Test group 2: tamsulosin 0.2 mg 1 times / d, plus Willitin 80 mg 2 times / d. After 2 weeks of treatment evaluation of treatment. Results After 2 weeks of treatment, the discharge time of stones in the control group, experimental group 1 and experimental group 2 were (8.4 ± 3.1) days, (6.6 ± 2.7) days and (5.9 ± 2.7) days, respectively. The control group and two experimental groups The difference was statistically significant (P <0.05), but there was no significant difference between the two experimental groups (P> 0.05). There were 22 cases (68.8%), 29 cases (90.6%) and 30 cases (93.8%) in control group, test group 1 and test group 2 respectively. The difference between the two test groups and the control group was statistically significant (P <0.05), but there was no significant difference between the two experimental groups (P> 0.05). There were 6 cases (18.8%), 4 cases (12.5%) and 3 cases (9.4%) treated with analgesic drugs because of renal colic in the three groups. The difference was not statistically significant (P> 0.05). Conclusion The combination of tamsulosin and Willlitin is safe and effective in treating lower ureteral calculi, which can increase the rate of discharged stone and shorten the time of row of stone.