先天性心包缺损是一种罕见的心血管疾病,可能伴发其他心内外畸形,由于临床上缺乏特征,很易被误诊或漏诊。中位心是指心脏的轮廓处于胸腔正中线的位置,也极为罕见,我院收治了1例先天性心包缺损合并中位心、室间隔缺损患者。1病例资料患者,女性,9岁,自幼易感冒,活动后偶有心慌、气短,发现心脏杂音5年入院。查体:发育较差,心率90次/分,律齐,胸骨左缘第3～4肋间可闻 Congenital pericardial defect is a rare cardiovascular disease may be associated with other cardiac and external deformities, due to the lack of clinical features, it is easy to be misdiagnosed or missed diagnosis. Median heart refers to the outline of the heart in the midline of the chest position, is also extremely rare, our hospital admitted to a case of congenital pericardial defect with central heart and ventricular septal defect. Case data 1, female, 9 years old, easy to catch a cold since childhood, occasional palpitation after the event, shortness of breath, heart murmur was found hospitalized for 5 years. Physical examination: poor development, heart rate 90 beats / min, law Qi, left sternal border 3 to 4 can be heard