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目的研究染色体核型分析在男性不育症患者中的诊断价值。方法收集精液分析合并染色体核型分析593例,胚胎停滞发育染色体分析94例,并将其分为:无精子症组,少精子症组,弱精子症组,及胚胎发育停滞组,综合分析各组染色体核型,分析异常的比例及分布特点。结果无精子症组染色体畸形率为29.4%,少精子症组患者中的染色体畸形率为18%,胚胎停止发育组中染色体畸形率41.2%,弱精子症及精子基本正常组染色体畸形率分别为10.8%及6.1%,无精子症及胚胎停滞发育组畸形率明显高于精液正常组。结论生精功能障碍越严重,染色体异常核型检出率越高,对生精功能障碍及胚胎发育停滞的患者,应必须进行染色体核型分析。
Objective To study the diagnostic value of karyotype analysis in male infertility patients. Methods 593 cases of semen analysis combined with chromosome karyotype analysis, 94 cases of embryo stasis developmental chromosome analysis were divided into four groups: azoospermia group, oligozoospermia group, asthenospermia group and embryo development arrest group. Group karyotypes, analysis of abnormal proportions and distribution characteristics. Results The rate of chromosome aberration was 29.4% in azoospermia group, 18% in the oligospermia group, and 41.2% in the embryo stop development group. The rates of chromosomal abnormalities in asthenospermia group and normal sperm group were 10.8% and 6.1% respectively. The rate of deformity in azoospermia and embryo stagnation group was significantly higher than that in normal semen group. Conclusions The more serious dysfunction of spermatogenesis is, the higher the detection rate of karyotype of chromosomal abnormalities, the analysis of chromosome karyotypes should be conducted in patients with spermatogenic dysfunction and embryo development stagnation.