论文部分内容阅读
近年来一些研究者试图从微生物的代谢产物中寻找免疫抑制药,时间虽不长,但已出现了有希望的苗头,如瑞士山道士公司从多孢木霉发酵液中提取的环孢菌素,日本东洋发酵株式会社从真青霉菌的发酵液中提取了Bredinin,法国巴斯德研究所从木贼镰刀菌菌体中分离出Cyclomunine等。在实验研究中它们都具有较好的免疫抑制作用,可延长移植器官的存活时间。前两者已在临床试用并有一定的疗效。由于微生物及其代谢产物的种类繁多,因而从微生物代谢产物中寻找免疫抑制剂可能是有希望的途径之一。国内有些单位已准备开展这方面的研究工作。本文仅就Bredinin的研究工作做一简要介绍。
In recent years, some researchers have tried to find immunosuppressive drugs from the metabolites of microorganisms for a long time, but promising signs have emerged such as the cyclosporin extracted from the polysaccharomyces cerevisiae by the Swiss mountain prodigal company , Japan Toyo fermentation Co., Ltd. extracted Bredinin from the broth of Penicillium sp., Pasteur Institute of France isolated Cyclomunine from Fusarium equiseti. In experimental studies, they all have good immunosuppressive effects, which can prolong the survival time of transplanted organs. The first two have been in clinical trials and have a certain effect. Because of the wide variety of microorganisms and their metabolites, finding immunosuppressants from microbial metabolites may be a promising approach. Some domestic units are ready to carry out research in this area. This article only gives a brief introduction of Bredinin’s research work.