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目的 :探讨大肠癌组织中 β-连环蛋白 (β- catenin)的表达是否与浸润、转移相关。方法 :应用免疫组化方法检测 44例大肠癌患者原发灶、临近非肿瘤大肠粘膜组织中的 β-连环蛋白的表达情况。结果 :正常大肠粘膜中 β-连环蛋白强烈表达 ,而其在大肠癌原发灶中的染色特征发生改变 ,表达程度明显弱于临近非肿瘤大肠粘膜 ,且与大肠癌的生长方式、分化程度、淋巴结转移、Dukes分期等临床病理因素密切相关。 结论 :β-连环蛋白的表达水平可以作为预测大肠癌转移潜能的一个参考指标。
Objective: To investigate whether the expression of β-catenin in colorectal cancer is related to infiltration and metastasis. METHODS: Immunohistochemistry was used to detect the expression of β-catenin in primary lesions and adjacent non-tumorous colorectal mucosa of 44 patients with colorectal cancer. RESULTS: β-catenin was strongly expressed in normal colorectal mucosa, and its staining characteristics in primary lesions of colorectal cancer were changed. The expression level was significantly weaker than that of adjacent non-tumor large intestine mucosa, and the growth pattern and degree of differentiation of colorectal cancer. Lymph node metastasis, Dukes staging and other clinical and pathological factors are closely related. Conclusion: The expression level of β-catenin can be used as a reference index to predict the metastatic potential of colorectal cancer.