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目的分析药品不良反应(ADR)发生规律和特点,为临床合理用药提供参考。方法收集连云港市东方医院2015年向国家药品不良反应监测系统上报的113例ADR报告,对患者的性别、年龄,ADR涉及的药物种类及给药方式,ADR涉及的抗菌药物类别、种类及例数,ADR涉及器官、系统的临床表现,ADR发生时间等进行统计分析。结果 113例ADR报告中,男53例(46.90%),女60例(53.10%);年龄1~83岁,其中19~60岁ADR发生率最高为61.06%。抗菌药物所致ADR居首位(66.37%),引起ADR的主要给药途径是静脉注射(92.92%),ADR涉及的器官或系统主要为皮肤及其附件,ADR主要发生在用药0.5h内。结论提升ADR监测工作力度,确保临床一线安全、有效、合理用药。
Objective To analyze the regularity and characteristics of adverse drug reaction (ADR) and provide reference for clinical rational drug use. Methods A total of 113 ADR cases reported by the Oriental Hospital of Lianyungang to the National Adverse Drug Reaction Monitoring System in 2015 were collected. The patients’ gender, age, types of drugs involved in ADR and the mode of administration, the categories, types and numbers of antibiotics involved in ADR , ADR involved organs, the clinical manifestations of the system, the occurrence of ADR and other statistical analysis. Results Among 113 ADR cases, 53 (46.90%) were male and 60 (53.10%) were female, ranging in age from 1 to 83 years. The highest incidence of ADR was 61.06% in 19 to 60 years old. ADR caused by antimicrobial drugs ranked the first place (66.37%). The main route of ADR caused by intravenous injection (92.92%) was ADR. The main organs or systems involved in ADR were skin and its appendages. ADR mainly occurred within 0.5 hours. Conclusion To improve the monitoring of ADR efforts to ensure that clinical first-line safe, effective and rational drug use.