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目的探讨辅助生育技术中控制性超排卵治疗对多囊卵巢综合征不孕患者卵母细胞质量的影响。方法对接受GnRH-a长方案降调控制性超排卵的多囊卵巢综合征患者50例(共52个周期),和同期因输卵管因素不孕接受GnRH-a长方案降调的对照组患者57例(共60个周期),观察取卵后卵-冠-丘复合物,对其卵母细胞质量进行评级,比较两组卵母细胞质量、成熟率、受精率、卵裂率、优质胚胎率和妊娠结局。结果 PCOS组3级卵母细胞数、优质胚胎数高于对照组,有显著性差异(P<0.05),而3级卵母细胞率、优质胚胎率与对照组相比无明显统计学差异(P>0.05),PCOS组1级、2级和4级卵母细胞数及比例与对照组相比无明显统计学差异(P>0.05)。PCOS组与对照组卵母细胞成熟率(88.0%vs88.3%)、受精率(79.3%vs 82.1%)、卵裂率(76.9%vs 80.3%)、临床妊娠率(38.5%vs 40.0%)等,差异无明显统计学意义(P>0.05)。结论 PCOS患者经促排卵治疗后,其优质卵母细胞数、优质胚胎数目明显高于正常对照组,能获得与正常对照患者相同的优质卵母细胞率、卵母细胞成熟率、受精率、卵裂率、优质胚胎率及临床妊娠率。
Objective To investigate the effect of controlled ovarian hyperstimulation (IVF) on the oocyte quality in infertile women with polycystic ovary syndrome (PCOS). Methods Fifty patients (52 cycles) with polycystic ovary syndrome who underwent GnRH-a long regimen down-regulation were compared with those in the control group who received a long-term GnRH-a regimen due to tubal infertility A total of 60 cycles were observed. The ovum-cumulus complex was observed and the oocyte quality was evaluated. The oocyte quality, maturation rate, fertilization rate, cleavage rate, quality embryo rate And pregnancy outcome. Results The number of oocyte and the number of high quality embryos in PCOS group were significantly higher than those in control group (P <0.05). However, there was no significant difference in grade 3 oocyte rate and high quality embryos compared with that in control group P> 0.05). There was no significant difference in the number of oocytes and the proportion of grade 1, grade 2 and grade 4 in PCOS compared with the control group (P> 0.05). The oocyte maturation rate (88.0% vs 88.3%), fertilization rate (79.3% vs 82.1%), cleavage rate (76.9% vs 80.3%) and clinical pregnancy rate (38.5% vs 40.0%) in PCOS group and control group The difference was not statistically significant (P> 0.05). Conclusions The number of high quality oocytes and high quality embryos in patients with PCOS after ovulation induction therapy was significantly higher than that of the normal control group, and the same high quality oocyte, oocyte maturation rate, fertilization rate, Cleavage rate, high quality embryo rate and clinical pregnancy rate.