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探讨药物流产 (药流 )后出血延长患者血一氧化氮 (NO)和环磷酸鸟苷 (cGMP)的变化及中药宫复合剂对药流后阴道流血延长的防治作用。对 12 0例自愿接受药流的早孕妇女 ,随机分为A、B两组 ,于口服米非司酮前、后及药流后 10d ,分别测血NO和cGMP。A组药流后服宫复合剂 7d ,B组药流后 7d内未予中药治疗。分别于药流后 10、2 0、30及 40d随诊。结果 :A、B两组口服米非司酮后 ,血清NO和血浆cGMP显著下降 (P <0 .0 5 )。药流后 10d ,A组阴道流血终止例数明显多于B组 (P<0 .0 5 )。A组药流后 10d血清NO和血浆cGMP均值显著低于B组 (P <0 .0 5 )。提示 :药流后血NO和cGMP浓度下降缓慢与药流后出血延长关系密切 ,中药宫复合剂对药流后出血延长有一定的防治作用。
To investigate the changes of blood nitric oxide (NO) and cGMP in patients with prolonged bleeding after medical abortion (drug abortion) and the preventive and therapeutic effects of Gonggui Mixture on prolonged vaginal bleeding after medical abortion. A total of 120 early pregnancy women who voluntarily received medical abortion were randomly divided into A and B groups. Before and after oral administration of mifepristone and 10 days after oral administration, blood levels of NO and cGMP were measured respectively. A group drug abortion Gongfu compound 7d, B group within 7d after drug flow without Chinese medicine treatment. Respectively 10,2 0,30 and 40d after medical abortion. Results: After oral administration of mifepristone, the levels of serum NO and plasma cGMP in groups A and B decreased significantly (P <0.05). After 10 days, the number of vaginal bleeding in group A was significantly more than that in group B (P <0.05). The serum NO and plasma cGMP in group A at 10 days after a drug flow were significantly lower than those in group B (P <0.05). It is suggested that the decrease of blood NO and cGMP concentration after medical abortion is closely related to the prolongation of bleeding after medical abortion, and the Chinese medicine Gongfu compound has some preventive and therapeutic effects on prolongation of medical abortion.