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目的：观察冬虫夏草（虫草）对人成纤维细胞ＩＣＡＭ－１及ＣＤ１２６表达的影响，探讨虫草抗肝纤维化的机制。方法：采用细胞培养法，于培养液中加入不同浓度的冬虫虫草。通过流式细胞仪观察经分子探针标记的ＩＣＡＭ－１及ＣＤ１２６阳性细胞数。结果：正常培养条件下，人成纤维细胞表达ＩＣＡＭ－１、ＣＤ１２６阳性率分别为（８６．６３±５．９４）％和（７７．９５±４．６８）％，虫草能明显抑制其表达。结论：冬虫虫草能抑制成纤维细胞表达某些细胞粘附分子，这可能是其抗肝纤维化机制之一。
Objective: To observe the effects of Cordyceps (Cordyceps militaris) on the expression of ICAM-1 and CD126 in human fibroblasts and to explore the mechanism of Cordyceps militaris on liver fibrosis. Methods: Cell culture method was used to add different concentrations of Cordyceps militaris to the culture solution. The number of ICAM-1 and CD126-positive cells labeled with the molecular probe was observed by flow cytometry. Results: Under normal culture conditions, the positive rates of ICAM-1 and CD126 expression in human fibroblasts were (86.63±5.94)% and (77.95±4.68)%, respectively, and Cordyceps could inhibit its expression. CONCLUSION: Cordyceps militaris can inhibit the expression of certain cell adhesion molecules in fibroblasts, which may be one of the mechanisms of anti-fibrosis.