论文部分内容阅读
溶血性尿毒综合征,其主需临床表现是:微血管病性溶血性贫血、血小板减少和急性肾病。主要见于婴幼儿,也可见于成人。病理改变是双侧肾皮质坏死,肾小球弥漫性或限局性坏死伴有输入小动脉内纤维蛋白沉积:肾小球毛细血管丛栓塞;肾小球内毛细血管及小动脉内皮细胞和上皮细胞肿胀增生。此外有25％的病例存在着透明血栓。本病主要发生于婴幼儿,也见于青少年。典型者在胃肠炎或上呼吸道感染后数天到二周突然发病,出现贫血、溶血、皮肤和粘膜出血、急性肾功衰竭,血象中出现畸形和碎片红细胞。本病的治疗,虽然不甚满意,但由于应用下列方法,取得了明显进步: 一、抗血小板药物 本病的主要病理改变是在微小血管中血小板血栓形成,因此,是应用抗血小板药物的适应症。常用阿斯匹林和潘生丁。
Hemolytic uremic syndrome, the main clinical manifestations are: microangiopathic hemolytic anemia, thrombocytopenia and acute nephropathy. Mainly seen in infants and young children can also be found in adults. Pathological changes are bilateral renal cortical necrosis, diffuse or localized glomerular necrosis associated with the importation of arteriolar fibrin deposition: glomerular capillary plexus; glomerular capillary and arteriolar endothelial cells and epithelial cells Swelling hyperplasia. In addition, 25% of cases have clear thrombus. The disease occurs mainly in infants and young children, but also seen in adolescents. Typical in gastroenteritis or upper respiratory tract infection within a few days to two weeks after the sudden onset of anemia, hemolysis, skin and mucous membrane bleeding, acute renal failure, abnormal bloodied and debris red blood cells. The treatment of this disease, although less than satisfactory, has made significant progress due to the following methods: 1. Antiplatelet drugs The main pathological changes of this disease are platelet thrombosis in minute blood vessels. Therefore, it is the application of antiplatelet drugs disease. Commonly used aspirin and dipyridamole.