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应用吡喃阿霉素和阿霉素为主联合化疗分别治疗２５例恶性淋巴瘤，进行对比观察。两组病例治疗有效率（ＣＲ＋ＰＲ）均为８８．０％，无差异。药物毒副反应白细胞减少、血小板减少、恶心、呕吐两组间均无显著性差异（Ｐ＞０．０５）。心脏、肝脏毒性及脱发发生率吡喃阿霉素组（１６．０％，０．０％及１６．０％）明显低于阿霉素组（２８．０％，１６．０％及５２．０％）（Ｐ＜０．０５，Ｐ＜０．０５，Ｐ＜０．０１）。
25 cases of malignant lymphoma were treated with pirarubicin and doxorubicin combined with chemotherapy, respectively, for comparison. Treatment efficiency (CR + PR) in both groups were 88.0%, no difference. Drug toxicity, leukopenia, thrombocytopenia, nausea and vomiting were not significantly different between the two groups (P> 0.05). Cardiac, hepatic toxicity and incidence of hair loss in the pirarubicin group (16.0%, 0.0%, and 16.0%) were significantly lower than those in the doxorubicin group (28.0%, 16.0%, and 52%). 0%) (P <0.05, P <0.05, P <0.01).