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在兔急性心肌缺血及再灌注情况下，我们用上海医科大学研制的 ＤＸＣ—４００型核孔滤膜细胞变形能力测定仪观察了兔红白细胞流变学变化，并用 一组动物术前给予硝苯啶药物，观察了此药对红白细胞流变学变化的影响．结果表 明，急性心肌缺血和再灌注情况下，红细胞滤过指数（ＩＦ）和白细胞阻塞离子浓度 （ＣＰ）都显著增高（Ｐ＜０．０１），用药组对红细胞变形能力的保护作用，出现显著效 果（Ｐ＜０．０１）．说明急性心肌缺血和再灌注均能显著改变红白细胞血液变学变 化，硝苯啶药物在改善器官灌流量的作用申，不但能扩张血管降低血压，而且还能 通过稳定红细胞变形能力，实现其对心脏的保护作用．
In rabbits with acute myocardial ischemia and reperfusion, we used the DXC-400 nuclear pore membrane deformability meter developed by Shanghai Medical University to observe the changes of erythrocyte rheology in rabbit and pretreatment with a group of animals Benzene pyridine drugs, observed the drug on the changes of erythroblast rheology. The results showed that the erythrocyte filtration index (IF) and leukocyte occlusion ion concentration (CP) were significantly increased in acute myocardial ischemia and reperfusion (P <0.01). The protective effect of the drug on erythrocyte deformability appeared Significant effect (P <0.01). It shows that both acute myocardial ischemia and reperfusion can significantly change the blood changes of erythroblasts, nifedipine drugs in improving the role of organ perfusion, not only can dilate blood vessels to lower blood pressure, but also through the stability of erythrocyte deformability, to achieve its The protection of the heart.