白杨黄素对大鼠离体主动脉的舒张作用

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白杨黄素(chrysin)存在于蜂蜜和蜂胶中,水果、蔬菜及饮料中亦有少量存在。曾报道许多黄酮类化合物能调节血管弹性,但是否具有内皮依赖性尚未阐明。作者研究了白杨黄素对雄性Wistar大鼠主动脉平滑肌弹性的影响及作用机理。结果显示,白杨黄素可浓度依赖地抑制去甲肾上腺素诱导的有完整内皮的大鼠主动 Chrysin is found in honey and propolis, and is found in small amounts in fruits, vegetables, and drinks. It has been reported that many flavonoids can modulate vascular elasticity, but whether there is endothelium-dependent has not been elucidated. The authors studied the effect of cortisone on the elasticity of aortic smooth muscle in male Wistar rats and the mechanism of action. The results showed that chrysin inhibited concentration-dependent inhibition of norepinephrine-induced rats with intact endothelium.
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