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目的 :探讨肿瘤坏死因子 (TNF)、白细胞介素 - 8(IL - 8)在小儿中枢神经系统感染性疾病中的意义。方法 :采用放射免疫方法 (RIA )对中枢神经系统感染的 40例患儿分别进行脑脊液中 TNF、IL - 8含量的检测 ,并与无中枢神经系统感染的 2 0例患儿进行比较。结果 :在疾病的急性期 ,细菌性脑膜炎患儿脑脊液中 TNF、IL - 8含量均显著高于对照组和病毒性脑炎组 ,P<0 .0 1。恢复期 ,菌脑组 TNF、IL - 8含量较治疗前明显下降 ,P<0 .0 1。结论 :脑脊液中TNF、IL - 8含量的检测有助于细菌性与非细菌性脑膜炎的诊断、鉴别诊断 ,并且还有助于细菌性脑膜炎的疗效观察。
Objective: To investigate the significance of tumor necrosis factor (TNF), interleukin - 8 (IL - 8) in children with central nervous system infectious diseases. Methods: The levels of TNF and IL - 8 in cerebrospinal fluid of 40 children with central nervous system infection were detected by radioimmunoassay (RIA) and compared with 20 children without central nervous system infection. Results: The levels of TNF and IL - 8 in cerebrospinal fluid in children with bacterial meningitis were significantly higher than those in control group and viral encephalitis group during the acute phase of the disease (P <0.01). During convalescence, the contents of TNF and IL - 8 in the cerebrum group were significantly lower than those before treatment (P <0.01). Conclusion: The detection of TNF and IL - 8 levels in cerebrospinal fluid is helpful for the diagnosis and differential diagnosis of bacterial and non - bacterial meningitis, and is also helpful for the observation of the curative effect of bacterial meningitis.