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以前的研究发现,恶性贫血和食物-维生素B_(12)吸收障碍(维生素B_(12)缺乏最常见的原因),尤其是在老年人均与慢性胃炎和可能与幽门螺杆菌感染有关。为进一步证实,胃肠道病学家对138例大红细胞性贫血和维生素B_(12)缺乏患者进行了一项前瞻性研究。这些病人不存在典型的原因如恶性贫血或胃切除后状态,但经胃活检被确认带有幽门螺杆菌。幽门螺杆菌感染用三元治疗方案根除,4周后通过胃活检证实是否根除。对所有病人进行间期为3个月的追访,长达5年。接受维生素B_(12)替代治疗的病人没有受到幽门螺杆菌的感染,除非幽门螺杆菌不能被根除。
Previous studies have found that pernicious anemia and food-vitamin B_ (12) malabsorption (the most common cause of vitamin B_ (12) deficiency) are especially associated with chronic gastritis and possibly Helicobacter pylori infection, especially in the elderly. To further confirm, gastroenterologists conducted a prospective study of 138 patients with erythroid cell anemia and vitamin B 12 deficiency. These patients do not have a typical cause such as pernicious anemia or state after gastrectomy, but gastric biopsy was confirmed with Helicobacter pylori. Helicobacter pylori infection was eradicated by a ternary regimen and confirmed by gastric biopsy 4 weeks after eradication. All patients were interviewed for a period of 3 months up to 5 years. Patients treated with vitamin B_ (12) replacement therapy are not infected with H. pylori unless H. pylori can not be eradicated.