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背景:随着胃癌病因研究的深入,目前发现许多宿主因素与胃癌的形成密切相关,白细胞介素(IL)-1β基因多态性成为重要的候选因素。目的:综合评价IL-1β-511等位基因及其基因型在胃癌发生中的作用,以期较深入地揭示IL-1β基因多态性与胃癌的关系。方法:共有7篇发表于1994年1月～2003年10月期间的有关IL-1β基因多态性与胃癌关系的国内外病例对照研究纳入荟萃分析,采用ReviewManager4.2统计软件对其结果进行定量综合分析。结果:以IL-1β-511位点的C/C基因型为对照,C/T、T/T和*/T基因型均为胃癌的危险因素,其OR值(95%CI)分别为1.78(1.51～2.10)、1.92(1.07～3.44)和1.79(1.54～2.07),但T/T基因型经敏感性分析后结果逆转。结论:IL-1β-511位点的C/T和*/T基因型是胃癌的危险因素,但T/T基因型与胃癌的关系尚未明确。
BACKGROUND: With the deep research on the etiology of gastric cancer, many host factors are found to be closely related to the formation of gastric cancer. Interleukin-1β gene polymorphism has become an important candidate. OBJECTIVE: To evaluate the role of IL-1β-511 allele and its genotype in gastric carcinogenesis in order to reveal the relationship between IL-1β gene polymorphism and gastric cancer. METHODS: A total of 7 case-control studies on the relationship between IL-1β gene polymorphism and gastric cancer from January 1994 to October 2003 were included in the meta-analysis and the results were quantified using ReviewManager 4.2 statistical software Comprehensive analysis. Results: C / T, T / T and * / T genotypes were all risk factors for gastric cancer with the C / C genotype at IL-1β-511 locus. The OR values (95% CI) were 1.78 (1.51 ~ 2.10), 1.92 (1.07 ~ 3.44) and 1.79 (1.54 ~ 2.07) respectively, but the results of T / T genotype were reversed after sensitivity analysis. CONCLUSION: C / T and * / T genotypes at IL-1β-511 locus are risk factors for gastric cancer. However, the relationship between T / T genotype and gastric cancer has not yet been clarified.