论文部分内容阅读
目的：观察３１例前列腺癌患者血清ＰＳＡ与ＰＴＨｒＰ的关系。方法：用放射免疫分析法（ＲＩＡ）和免疫放射分析法（ＩＲＭＡ）。结果：１）正常组测得血清ＰＳＡ值为２．０±１．４４μｇ／Ｌ（ｘ±ｓ），血清ＰＴＨｒＰ（１～８６）值为１．６±０．６ｐｍｏｌ／Ｌ（ｘ±ｓ）。２）前列腺癌组测得血清ＰＳＡ值为８０±５２．５５μｇ／Ｌ（ｘ±ｓ），ＰＴＨｒＰ测得值为４．５８±４．４０ｐｍｏｌ／Ｌ（ｘ±ｓ），显著高于健康组（ｔ＝２．７４９，Ｐ＜０．０１和ｔ＝２．７５，Ｐ＜０．０１）。３）２１例伴发ＨＨＭ前列腺癌患者，ＰＴＨｒＰ（１～８６）升高的有１３例，占６１．９％（１３／２１），测得均值为７．４ｐｍｏｌ／Ｌ（２．８８～１９．１ｐｍｏｌ／Ｌ）。４）２１例伴发ＨＨＭ前列腺癌患者ＰＳＡ和ＰＴＨｒＰ浓度呈显著正相关（ｒ＝０．８２３，Ｐ＜０．０１）。结论：血清ＰＳＡ和ＰＴＨｒＰ的联合测定可作为前列腺癌诊断与疗效监测的指标
Objective: To observe the relationship between serum PSA and PTHrP in 31 cases of prostate cancer. Methods: Radioimmunoassay (RIA) and immunoradiometric assay (IRMA) were used. Results: The serum PSA level of normal group was 2.0 ± 1.44μg / L (x ± s) and the serum PTHrP (1 ~ 86) was 1.6 ± 0.6pmol / L (x ± s) . 2) The PSA value of prostate cancer group was 80 ± 52.55μg / L (x ± s), PTHrP was 4.58 ± 4.40pmol / L (x ± s), which was significantly higher than that of healthy group t = 2.749, P <0.01 and t = 2.75, P <0.01). 3) Twenty-one patients with HHM prostate cancer had thirteen cases of elevated PTHrP (1-86), accounting for 61.9% (13/21), with a mean of 7.4 pmol / L (2.88-19 .1 pmol / L). There was a significant positive correlation between PSA and PTHrP concentrations in 21 patients with HHM prostate cancer (r = 0.823, P <0.01). Conclusion: The combination of serum PSA and PTHrP can be used as an indicator of the diagnosis and curative effect of prostate cancer