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目的探讨布比卡因复合舒芬太尼用于硬膜外分娩镇痛的适宜浓度。方法60例足月初产妇,随机分为2组,每组30例。第一、二产程所有产妇均于硬膜外持续泵注镇痛液。S组(舒芬太尼组)镇痛液配方为0.1125%布比卡因复合0.5μg/ml舒芬太尼共100 ml;C组(对照组)镇痛液配方为0.15%布比卡因100 ml。结果在第一产程中,S组完全无疼痛者明显比C组多(66.7%:33.3%)(P<0.01);S组产妇中出现轻度运动阻滞者明显比C组多(76.7%:33.3%)(P<0.01),而中度阻滞者明显少于C组(20%:60%)(P<0.01),两组间比较差异有统计学意义。结论第一、第二产程在硬膜外持续输注0.1125%布比卡因+0.5μg/ml舒芬太尼,镇痛效果优于单纯输注0.15%布比卡因;对运动神经的阻滞发生率低于后者,阻滞程度也较轻,是一种较为理想的分娩镇痛浓度。
Objective To investigate the suitable concentration of bupivacaine combined with sufentanil for epidural analgesia. Methods 60 cases of full-term primipara, were randomly divided into two groups, 30 cases in each group. The first and second stage of all mothers in the epidural continuous pump analgesic fluid. S group (sufentanil group) analgesic formula 0.1125% bupivacaine 0.5μg / ml sufentanil 100ml; C group (control group) analgesic formulation of 0.15% bupivacaine 100 ml. Results In the first stage of labor, the patients with no pain in group S were significantly more than those in group C (66.7% vs 33.3%) (P <0.01); those in group S were more likely to have mild motor block than those in group C (76.7% : 33.3%) (P <0.01), while those with moderate block were significantly less than those in group C (20%: 60%) (P <0.01). There was significant difference between the two groups. Conclusions The first and second stage of labor were sustained epidural infusion of 0.1125% bupivacaine plus 0.5μg / ml sufentanil, and the analgesic effect was better than that of infusion of 0.15% bupivacaine alone. The resistance to motor nerve Lag than the latter, the degree of block is also lighter, is a more ideal concentration of labor analgesia.