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患者男,62岁。因尿急、尿频、排尿困难5天,于1999年4月3日入院治疗。患者有高血压史10余年,BP为150/90mmHg。无癫痫病史,前列腺液常规镜检:WBC增多,卵磷脂小体减少,并有散在的脓细胞,诊断为前列腺炎。给予甲磺酸培氟沙星注射液 0.4g加入5％葡萄糖氯化钠注射液 250ml,静脉滴注,q12h。用药后2天排尿困难逐渐减轻,第3天静脉滴注时,患者突然意识丧失,口吐白沫、牙关紧闭、两眼上翻、四肢抽搐、角弓反张呈癫痫大发作表现。立即停用甲磺酸培氟沙星注射液,给予地西泮10mg,肌注,约20min后症状缓解。脑电图提示各导联广泛异常。考虑为甲磺酸培氟沙星注射液所致的癫痫大发作,停用甲磺酸培氟沙星注射液,改为其它类抗菌药物,未见再次癫痫发作。
Male patient, 62 years old. Due to urgency, frequent urination, difficulty urinating 5 days, on April 3, 1999 admitted to hospital. Patients with hypertension history of more than 10 years, BP 150 / 90mmHg. No history of epilepsy, prostatic fluid routine microscopy: WBC increased, reduced lecithin, and scattered pus cells, the diagnosis of prostatitis. Given pefloxacin mesylate injection 0.4g 5% glucose and sodium chloride injection 250ml, intravenous infusion, q12h. 2 days after treatment, dysuria gradually reduced, the first three days of intravenous drip, the patient suddenly lost consciousness, foaming at the mouth, mouth closed, eyes upturned, limbs convulsions, antinocortical epileptic seizures show. Immediately disable the pefloxacin mesylate injection, given diazepam 10mg, intramuscular injection, about 20min after the symptoms were relieved. EEG prompted extensive abnormal lead. Considering the epileptic seizures caused by pefloxacin mesylate injection, the pefloxacin mesylate injection was discontinued and replaced with other antibacterial drugs. No seizures were found.