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雄性ＳＤ大鼠连续每日摄入ＬＡＳ５５～６５ｍｇ／ｋｓ１２周。１周后肝Ｐ４５０和氨基比林脱甲基酶均明显升高（Ｐ＜０．０５），Ｐ４４８ＥＲＯＤ也出现升高趋势；第３，６周后各指标恢复至对照水平；从第９周起Ｐ４５０又开始高于对照并持续至第１２周；苯胺羟化酶在第９周也有升高。结果指示，ＬＡＳ短期染毒对Ｐ４５０、Ｐ４４８（ＥＲＯＤ）和氨基比林脱甲基酶，长期染毒对Ｐ４５０均有诱导升高作用，表明ＬＡＳ对机体影响的潜在作用存在，值得注意。
Male Sprague-Dawley rats were enrolled in daily LAS55 ~ 65mg / ks for 12 weeks. After 1 week, the demethylase of liver P450 and aminopyrine were significantly increased (P <0.05), and P448EROD also increased. After the 3rd and 6th week, the indexes returned to the control level; from the 9th week P450 began to be higher than the control and continued to the twelfth week; aniline hydroxylase also increased in the 9th week. The results indicated that short-term exposure of LAS to P450, P448 (EROD) and aminopyrine demethylase, long-term exposure to P450 induced elevation, indicating that the potential impact of LAS on the body exists, it is worth noting.