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[目的]研究慢性浅表性胃炎(CSG)胃黏膜增殖细胞核抗原(Proliferating cell nuclear antigen,PCNA)和热休克蛋白60(Heat shock protein 60,HSP60)的表达与中医证型的关系。[方法]免疫细胞化学技术检测CSG患者不同证型胃窦黏膜内PCNA和HSP60的水平。[结果]CSG脾气虚证PCNA胃黏膜内的细胞分裂指数高于脾胃湿热证(P<0.05);脾胃湿热证胃黏膜内的HSP60在间质和腺体均高于脾气虚证(P<0.05,<0.01),而2种证型HSP60在胃黏膜上皮的表达比较差异无统计学意义(P>0.05)。[结论]中医的临床辨证分型与PCNA和HSP60表达有一定关系。
[Objective] To investigate the relationship between expression of proliferating cell nuclear antigen (PCNA) and heat shock protein 60 (HSP60) in the stomach of chronic superficial gastritis (CSG) and TCM syndromes. [Method] Immunocytochemistry was used to detect the levels of PCNA and HSP60 in gastric mucosa of different syndromes in CSG patients. [Results] The cell division index of PCNA in spleen deficiency syndrome of CSG was higher than that of spleen-stomach damp-heat syndrome (P <0.05). HSP60 in gastric mucosa of spleen-stomach damp-heat syndrome was higher than that of spleen- , <0.01). There was no significant difference in the expression of HSP60 in gastric mucosal epithelium between the two syndromes (P> 0.05). [Conclusion] The clinical syndrome differentiation of TCM is related to the expression of PCNA and HSP60.