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目的观察复方连芩双层缓释药膜联合金莲清热泡腾片治疗小儿手足口病及对其血清因子水平的影响。方法将200例手足口病患儿随机分为试验组和对照组各100例。试验组给予复方连芩双层缓释药膜与金莲清热泡腾片联合常规方法治疗,对照组仅给予金莲清热泡腾片和常规治疗。对比观察2组患者的治疗效果及血清细胞因子水平变化。结果试验组患者治疗后总有效率为96.0%高于对照组的82.0%,差异有统计学意义(P<0.05)。2组患者治疗前血清白细胞介素-6(IL-6)、白细胞介素-12(IL-12)和白细胞介素-1β(IL-1β)水平差异均无统计学意义(P>0.05)。治疗后2组患者上述细胞因子水平均有所降低,且试验组降低幅度明显大于对照组,差异均具有统计学意义(P<0.05)。结论复方连芩双层缓释药膜与金莲清热泡腾片联合常规方法治疗小儿手足口病具有显著的疗效,并有效降低血清IL-6、IL-12及IL-1β水平。
Objective To observe the effect of compound double-drug sustained-release double-coated sustained-release film and Jinlian heat effervescent tablet on children’s hand, foot and mouth disease and its serum factor level. Methods 200 cases of hand, foot and mouth disease were randomly divided into experimental group and control group of 100 cases. The experimental group was given Lianlian double-coated sustained-release drug film and Jinlian heat effervescent tablets combined with conventional treatment, the control group was given only Jinlian heat effervescent tablets and conventional treatment. The therapeutic effects and the changes of serum cytokines were compared between two groups. Results The total effective rate of the experimental group after treatment was 96.0% higher than 82.0% of the control group, the difference was statistically significant (P <0.05). The levels of serum IL-6, IL-12 and IL-1β in two groups had no significant difference before treatment (P> 0.05) . After treatment, the levels of these cytokines decreased in both groups, and the reduction in the experimental group was significantly greater than that in the control group (P <0.05). Conclusion The combination of Lianqian Lianqin double-coated sustained-release film and Jinlian heat effervescent tablet combined with conventional method has significant curative effect on children’s hand-foot-mouth disease and effectively reduces the levels of serum IL-6, IL-12 and IL-1β.