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肝脏使人体重要的生命器官之一,也是生物转化的重要器官,当肝脏受到大量的酒精刺激和侵袭时,会引起酒精性肝病[1]。近年来,随着人们生活水平的提高,应酬增多,对饮酒的需求增大,由此,酒精性肝病的发病率(ALD)也逐年增加。诊断肝病的酶类有几十种,由于酶类化学反不同,分布部位不同。当肝脏发生病变时,细胞膜的通透性增加,各种酶释放入血,导致酶的活性增高。过去诊断ALD常用的生化指标如r-谷氨酰基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)等缺乏特异性。近来国内外对天门冬氨酸氨基转移酶线粒体同工酶(m-AST)的研究较多。本研究用免疫抑制法对ALD患者血清中m-AST进行了检测,并与GGT、AST、ALT、TBA等指标进行了比较,评价其对ALD的诊断价值。
The liver makes one of the important vital organs of the human body, and also an important organ for biotransformation, which causes alcoholic liver disease when the liver is heavily stimulated and infused with alcohol. In recent years, as people’s living standards improve, entertainment increases, the demand for drinking increases, thus, the incidence of alcoholic liver disease (ALD) also increased year by year. There are dozens of enzymes for the diagnosis of liver disease, due to different anti-enzyme chemistry, distribution of different parts. When the liver lesions, the permeability of the cell membrane increased, various enzymes released into the blood, leading to increased enzyme activity. In the past, common biochemical markers of ALD, such as r-glutamyl transferase (ALT) and aspartate aminotransferase (AST), were lacking in specificity. Recently, aspartate aminotransferase mitochondrial isoenzyme (m-AST) research more. In this study, m-AST in serum of patients with ALD was detected by immunosuppression, and compared with GGT, AST, ALT, TBA and other indicators to evaluate its diagnostic value of ALD.