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目的观察痰热清注射液对放疗后血浆中白介素-6(IL-6)及血管紧张素转换酶(ACE)含量影响以及对防治放射性肺炎的疗效。方法将88例肺癌患者随机分为两组,观察组45例放射治疗同时予痰热清注射液静滴,对照组43例只予常规放射治疗。放疗前及照射40～55Gy后分别采血冻存,采用酶联免疫吸附法检测血浆中IL-6及ACE含量。结果观察组放射性肺炎发生率17.78%(8/45),对照组37.21%(16/43);其中3、4级观察组为4.44%(2/45),对照组30.23%(13/43)(P<0.05)。观察组放疗前后IL-6分别为(9.13±3.72)和(7.57±2.22),对照组(8.76±2.87)和(10.50±4.00),放疗后两组差异有统计学意义(P<0.05)。观察组放疗前后ACE分别为(449.05±136.78)和(798.56±211.79),对照组为(494.00±203.79)和(132.37±58.38),放疗后两组差异有统计学意义(P<0.05)。结论痰热清注射液能降低血浆中IL-6的表达,能提高血浆中ACE的表达,有效预防和推迟严重性急性放射性肺炎的发生。
Objective To observe the effects of Tanreqing Injection on the levels of interleukin-6 (IL-6) and angiotensin-converting enzyme (ACE) in plasma after radiotherapy, and to evaluate the efficacy of radiotherapy for preventing and treating radiation pneumonitis. Methods Eighty-eight patients with lung cancer were randomly divided into two groups. In the observation group, 45 patients received intravenous injection of Tanreqing Injection while 45 patients in the control group received conventional radiotherapy only. Pre-radiotherapy and irradiation 40 ~ 55Gy were collected after cryopreservation, plasma IL-6 and ACE levels were detected by enzyme-linked immunosorbent assay. Results The incidence of radiation pneumonitis in the observation group was 17.78% (8/45) in the control group and 37.21% (16/43) in the control group, with 4.44% (2/45) in the third and fourth grade observation groups and 30.23% (13/43) in the control group, (P <0.05). The levels of IL-6 in the observation group before and after radiotherapy were (9.13 ± 3.72) and (7.57 ± 2.22) and in the control group (8.76 ± 2.87) and (10.50 ± 4.00) respectively. There was significant difference between the two groups after radiotherapy (P <0.05). The ACE of the observation group before and after radiotherapy were (449.05 ± 136.78) and (798.56 ± 211.79) and 494.00 ± 203.79 and (132.37 ± 58.38), respectively. There was significant difference between the two groups after radiotherapy (P <0.05). Conclusion Tanreqing Injection can reduce the expression of IL-6 in plasma, increase the expression of ACE in plasma and effectively prevent and delay the occurrence of severe acute radiation pneumonitis.