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目的观察镍钛记忆合金硅橡胶避孕栓的毒性反应、组织学改变。方法镍钛记忆合金和硅橡胶制成输卵管避孕栓。18只山羊在常规消毒下提出右侧子宫及输卵管,在近宫角2cm处切开1·5cm纵切口,行右侧输卵管栓堵,将输卵管栓放入输卵管,左侧为自身对照。术后1周、2周、1、3、6、12个月各随访1次,每次有3只山羊将双侧输卵管及实验侧的输卵管栓子同时取出送病理,观察毒性反应及组织学变化。结果山羊放置输卵管栓子术后1周、2周、1、3、6、12个月肉眼观察均无异常。组织学检查,术后1周输卵管内见有少量炎性细胞渗出、管腔变窄、但管壁无明显变化,也无周围组织粘连。术后半月~6个月,黏膜正常,黏膜下肌层无增生及萎缩,无炎性细胞浸润,浆膜无明显病理异常。术后12个月,输卵管内膜腺体和纤维细胞轻度增生,但浆膜无明显改变。结论镍钛记忆合金硅橡胶可复性输卵管栓放置后组织相容性好,无明显组织学改变及毒副反应。
Objective To observe the toxicity and histological changes of NiTi silicone rubber contraception. Methods NiTi memory alloy and silicone rubber made of tubal contraceptives. 18 goats in the routine disinfection of the right uterus and fallopian tube proposed at 2cm near the angle of the incision of 1.5cm longitudinal incision, the right tubal plug, the tubal suppository into the fallopian tube, the left for their own control. One week, two weeks, one, three, six, and twelve months after operation, each follow-up was performed 1 time. Three goats at the same time took bilateral tubal and tubal emboli on the experimental side at the same time and sent them to the pathological examination to observe the toxicity and histology Variety. Results There was no abnormality in macroscopic observation at 1 week, 2 weeks, 1, 3, 6, and 12 months after oviduct implantation in goats. Histological examination, see a small amount of inflammatory cell exudation in the fallopian tube after 1 week, narrowing of the lumen, but no significant changes in the wall, nor the surrounding tissue adhesions. After half a month to 6 months, normal mucosa, submucosal muscle layer without proliferation and atrophy, no inflammatory cell infiltration, serosa no significant pathological abnormalities. At 12 months after operation, tubal glandular cells and fibroblasts were mildly hyperplastic, but serosa did not change significantly. Conclusion Nitinol memory alloy silicone rubber retractable tubal placement of good histocompatibility, no significant histological changes and toxic side effects.