乏氧细胞放射敏感性要比有氧细胞差2.5～3倍,实体瘤中乏氧细胞是治疗肿瘤的不利因素,往往使用高压氧,高LET 及放射增敏剂来改善这种状况.简便有效的方法是使用一种对乏氧细胞选择性增敏,而对正常的有氧细胞又无影响的化学药物.Nitroi-midazole 的衍生物在培养的乳癌细胞及某些动物肿瘤模型中,misonida zole 是一种有效的乏氧细胞增敏剂.日本在1976年就开始了药物试验研究,1979年进行临床试验,提供了其安全性及效果.本文报道作者早期使用misonidazole 的临床结果. The radiosensitivity of hypoxic cells is 2.5 to 3 times worse than that of aerobic cells. Hypoxic cells in solid tumors are unfavorable factors in the treatment of tumors. Hyperbaric oxygen, high LET and radiosensitizers are often used to improve this condition. The method is to use a chemical drug that selectively sensitizes hypoxic cells and has no effect on normal aerobic cells. Nitroi-midazole derivatives are used in cultured breast cancer cells and some animal tumor models, misonida zole It is an effective hypoxic cell sensitizer. Japan began drug trials in 1976 and clinical trials in 1979, providing its safety and efficacy. This article reports the clinical results of the author’s early use of misonidazole.