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目的探讨亲缘单倍体造血干细胞联合间充质干细胞共移植治疗重型再生障碍性贫血的疗效。方法报告1例亲缘单倍体造血干细胞联合间充质干细胞共移植治疗重型再障患者的疗效并对有关文献进行复习。结果移植后患者造血功能恢复迅速,仅有Ⅱ度急性移植物抗宿主病发生,无明显感染及其他并发症发生。结论单倍体造血干细胞联合间充质干细胞治疗重型再生障碍性贫血是有效、可行的。
Objective To investigate the effect of co-transplantation of haploid hematopoietic stem cells and mesenchymal stem cells in treatment of severe aplastic anemia. Methods One case of haploidentical haploidentical hematopoietic stem cells combined with mesenchymal stem cell transplantation for the treatment of patients with severe aplastic anemia was reviewed and the relevant literature was reviewed. Results The hematopoietic function recovered quickly after transplantation. Only grade Ⅱ acute graft-versus-host disease occurred, with no obvious infection and other complications. Conclusions Haploid hematopoietic stem cells combined with mesenchymal stem cells are effective and feasible for the treatment of severe aplastic anemia.