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目的观察依达拉奉注射液治疗急性脑梗死的疗效。方法将起病24 h内急性脑梗死患者120例随机分为治疗组和对照组各60例,其中治疗组给予依达拉奉注射液30 mg,加入生理盐水100 ml,2次/d,静脉滴注7d,7d后改为依达拉奉30 mg,加入生理盐水100 ml,1次/d,总共14 d,同时给予丹红注射液20 ml加入生理盐水250 ml,1次/d,静脉滴注,共14d;对照组给予血塞通400 mg加入生理盐水250 ml,静脉滴注,1次/d,并给予胞磷胆碱钠0.5g加入生理盐水250 ml,静脉滴注,1次/d,共14 d。结果治疗组总有效率为96.7%明显优于对照组的68.3%,两组差异有统计学意义(P<0.05)。结论本治疗方案优于普通治疗方案,疗效理想,并能更好的抑制脑细胞及脂质过氧化,减少血管内皮细胞及神经细胞的氧化损伤,清除自由基。依达拉奉注射液加丹红注射液治疗急性脑梗死效果显著,值得在临床推广和应用。
Objective To observe the curative effect of edaravone injection on acute cerebral infarction. Methods 120 patients with acute cerebral infarction within 24 hours after onset were randomly divided into treatment group and control group of 60 cases. The treatment group was treated with edaravone 30 mg injection, saline 100 ml, twice daily, intravenous Instillation of 7d, 7d after edaravone 30mg, adding saline 100ml, 1 time / d, a total of 14 d, while giving Danhong injection 20 ml saline 250ml, 1 / d, intravenous Drip, a total of 14d; control group given Xuesaitong 400 mg saline 250 ml, intravenous infusion, 1 / d, and given citicoline 0.5g saline 250 ml, intravenous infusion, 1 / d, a total of 14 d. Results The total effective rate was 96.7% in the treatment group was significantly better than 68.3% in the control group, the difference between the two groups was statistically significant (P <0.05). Conclusion The treatment regimen is superior to ordinary treatment regimens, with good curative effect and better inhibition of brain cells and lipid peroxidation, reducing oxidative damage of vascular endothelial cells and nerve cells, and scavenging free radicals. Edaravone injection plus Danhong injection in the treatment of acute cerebral infarction significant effect, it is worth in the clinical promotion and application.