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目的探讨分析女性人类免疫缺陷病毒(Human Immunodeficiency Virus,HIV)与宫颈人乳头瘤状病毒(Human papillomavirus,HPV)感染的相关性。方法选择2014年6月-2016年6月自愿接受HPV筛查的HIV阳性女性161例为HIV阳性组,将自愿接受HPV筛查的HIV阴性女性180例为HIV阴性组,采取PCR与膜杂交法检测受试者宫颈脱落细胞以及宫颈黏液标本,并进行HPV病毒基因分型,分析HIV阳性患者HPV感染对细胞免疫影响。结果 HIV阳性组高危型HPV感染率为38.51%,低危型HPV感染率为15.53%,HPV多重感染率为19.25%;HIV阴性组高危型HPV感染率为16.11%,低危型HPV感染率为5.56%,HPV多重感染率为7.78%。HIV阳性组高危型HPV感染率、低危型HPV感染率以及HPV多重感染率均显著高于HIV阴性组(P<0.05)。在HIV阳性患者中,合并HPV感染患者其CD3~+、CD4~+、CD4~+/CD8~+水平显著低于未合并HPV感染患者(P<0.05);合并HPV感染患者CD8~+水平显著高于未合并HPV感染患者(P<0.05);HIV阳性合并HPV阳性患者获得性免疫缺乏综合征(Acquired Immune Deficiency Syndrome,AIDS)临床分期较HIV阳性HPV阴性患者更为严重(P<0.05)。结论HIV阳性女性较HIV阴性女性感染HPV病毒的风险更高,可能与机体T淋巴细胞免疫抑制以及AIDS临床分期有关,应将HIV感染女性作为HPV感染的高危人群进行筛查,以及时确定预防和治疗方案。
Objective To explore the relationship between human immunodeficiency virus (HIV) and human papillomavirus (HPV) infection. Methods Sixty-one HIV-positive women who voluntarily received HPV screening from June 2014 to June 2016 were HIV-positive and 180 HIV-negative women who voluntarily received HPV screening were HIV-negative. PCR and membrane hybridization The cervical exfoliated cells and cervical mucus specimens of the subjects were tested, and HPV genotypes were performed. The effects of HPV infection on cellular immunity were analyzed. Results The prevalence of high-risk HPV was 38.51% in HIV-positive group, 15.53% in low-risk group and 19.25% in HPV-negative group. The prevalence of high-risk HPV was 16.11% in HIV-negative group, 5.56%, HPV infection rate was 7.78%. High-risk HPV infection rate, low-risk HPV infection rate and multiple HPV infection rate in HIV-positive group were significantly higher than those in HIV-negative group (P <0.05). In HIV-positive patients, the levels of CD3 +, CD4 +, CD4 + / CD8 + in patients with HPV infection were significantly lower than those without HPV infection (P <0.05). The levels of CD8 + in patients with HPV infection were significantly higher than those without HPV infection (P <0.05). The clinical stage of Acquired Immune Deficiency Syndrome (HIV) in HIV-positive patients with HPV-positive was more serious than that of HIV-positive HPV-negative patients (P <0.05). Conclusion HIV-positive women are at a higher risk of HPV infection than HIV-negative women, which may be related to the immunosuppression of T lymphocytes and the clinical stage of AIDS. HIV-infected women should be screened at high risk of HPV infection and the prevention and / Treatment programs.