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作者采用Hewitt非参数排列法,对四川省遗传病及先天畸形流行病学调查资料中发病早、不致早期死亡的41种疾病进行发病季节性研究,发现大多数遗传病和先天(发育)畸形发病不存在季节性波动。但染色体病中的21-三体综合征,多基因遗传病中的腹股沟疝、先天性足畸形及非遗传性疾病中的精索静脉曲张等发病具有季节性波动。本研究还发现先天性聋哑症发病存在季节性(P=0.0134)。本文还就研究季节性的其它方法进行了比较和讨论。
The authors used Hewitt non-parametric permutation method to study the seasonal epidemiology of 41 diseases that were diagnosed early and did not cause early death in the epidemiological data of genetic diseases and congenital malformations in Sichuan Province and found that most of the genetic diseases and congenital (developmental) malformations There are no seasonal fluctuations. However, 21-trisomy syndrome in chromosome disease, polygenic disease in inguinal hernia, congenital foot deformity and non-genetic diseases such as varicocele and other seasonal fluctuations. The study also found that the incidence of congenital deaf disease is seasonal (P = 0.0134). This article also compares and discusses other ways to study seasonality.