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为探讨G6PD缺陷症溶血机制 ,采用彩色免疫单扩散法测定 2 9例G6PD缺陷症急性溶血时血清补体C3及IgG、IgA、IgM。同时测定 30例年龄相当的择期行疝囊结扎术患儿术前血清C3及免疫球蛋白。结果 ,G6PD组C3、IgG、IgA、IgM分别为 (0 .96 3± 0 .2 41 )g/L、(6 .6 31± 1 .31 6 )g/L、(0 .70 3± 0 .2 2 3)g/L、(0 .90 7± 0 .2 70 )g/L ,而对照组为 (0 .85 3± 0 .2 73)g/L、(7.0 31± 1 .484)g/L、(0 .740± 0 .432 )g/L、(0 .841± 0 .2 70 )g/L。两组比较均无显著差异 (P >0 .0 5 )。结果表明 ,G6PD缺陷症急性溶血时无补体C3的激活 ,也无明显免疫球蛋白水平的变化
In order to investigate the hemolysis mechanism of G6PD deficiency, the serum complement C3 and IgG, IgA and IgM in 29 patients with acute G6PD deficiency were measured by colorimetric immunodiffusion. Simultaneous determination of preoperative serum levels of C3 and immunoglobulin in 30 age-matched hernia sac ligation patients. Results: The levels of C3, IgG, IgA and IgM in G6PD group were (0.96 3 ± 0.21 1) g / L, (6 .631 ± 1.31 6) g / L, (0.703 ± 0 .2 2 3) g / L, (0.90 7 ± 0.22 70) g / L, while the control group was (0.853 ± 0.223) g / L, (7.031 ± 1.484 ) g / L, (0.740 ± 0.342) g / L, (0.0841 ± 0.272) g / L. There was no significant difference between the two groups (P> 0.05). The results showed that G6PD deficiency in acute hemolysis without complement C3 activation, but also no significant changes in immunoglobulin levels