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目的观察免疫球蛋白联合甲泼尼龙治疗急性格林巴利综合征(GBS)的临床效果。方法 104例急性GBS患者,根据入院顺序随机分为观察组和对照组,各52例。对照组采用免疫球蛋白常规治疗,观察组在对照组治疗基础上加用甲泼尼龙治疗,比较两组患者的临床疗效。结果经积极治疗,观察组显效19例,有效28例,无效5例,总有效率为90.4%;对照组显效14例,有效25例,无效13例,总有效率为75.0%。观察组总有效率优于对照组(P<0.05)。结论在免疫球蛋白治疗基础上加用甲泼尼龙治疗急性GBS能显著提高治疗有效率,改善患者预后,值得临床推广。
Objective To observe the clinical effect of immunoglobulin combined with methylprednisolone in the treatment of acute Guillain-Barre syndrome (GBS). Methods A total of 104 patients with acute GBS were randomly divided into observation group and control group according to admission sequence, each with 52 cases in each group. Control group immunoglobulin routine treatment, the observation group on the basis of the control group plus methylprednisolone treatment, the clinical efficacy of the two groups were compared. The results of active treatment, the observation group of 19 cases markedly effective in 28 cases, 5 cases of ineffective, the total effective rate was 90.4%; the control group markedly effective in 14 cases, effective in 25 cases, ineffective in 13 cases, the total effective rate was 75.0%. The total effective rate in observation group was better than that in control group (P <0.05). Conclusion The addition of methylprednisolone to acute GBS on the basis of immunoglobulin therapy can significantly improve the treatment efficiency and improve the prognosis of patients, worthy of clinical promotion.