论文部分内容阅读
目的揭示血清白细胞介素6(IL-6)水平在脓毒症患者体内变化规律及意义。方法分别抽取40例APACHEⅡ评分>12分的脓毒症患者和30例正常人的外周血,应用放射免疫分析法检测其血清IL-6水平。将这2组血清IL-6水平进行比较。同时将脓毒症组的IL-6水平与病人的预后、APACHEⅡ评分作相关性分析。结果脓毒症组血清IL-6水平[(152.02±55.77)pg/m l],与正常对照组IL-6[(85.79±30.96)pg/m l]比较差异有统计学意义(P<0.01)。脓毒症组血清IL-6水平与病人的预后呈正相关(r=0.667,P=0.000),与APACHEⅡ评分呈正相关(r=0.485,P=0.002)。40例感染患者中有20例死亡,他们的血清IL-6水平[(186.20±48.74)pg/m l]较生存病例[(117.84±39.36)pg/m l]高(t=4.880,P=0.000)。结论脓毒症时,血清IL-6水平升高,其升高反应了感染的严重程度,与预后有较好的相关性。
Objective To reveal the change and significance of serum interleukin 6 (IL-6) levels in sepsis patients. Methods Peripheral blood of 40 patients with sepsis with APACHEⅡ score> 12 and 30 normal controls were collected. Serum IL-6 levels were measured by radioimmunoassay. The two groups of serum IL-6 levels were compared. At the same time, the level of IL-6 in sepsis group was correlated with the prognosis of patients and the APACHEⅡscore. Results Serum IL-6 level in sepsis group was significantly higher than that in control group [(152.02 ± 55.77) pg / m l] (85.79 ± 30.96 pg / m l) (P <0.01). Serum IL-6 level in sepsis group was positively correlated with patient’s prognosis (r = 0.667, P = 0.000), and positively correlated with APACHEⅡscore (r = 0.485, P = 0.002). Twenty of the 40 infected patients died and their serum IL-6 levels [(186.20 ± 48.74) pg / ml] were higher than those of the survivors [(117.84 ± 39.36) pg / ml] . Conclusions In sepsis, the level of serum IL-6 is increased, and its elevation reflects the severity of infection and has a good correlation with prognosis.