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双性癌是混合性腺神经内分泌癌(mixed adenoneuroendocrine carcinoma,MANEC)的特殊类型,定义为肿瘤细胞同时具有腺上皮和神经内分泌分化。MANEC相对罕见,双性癌则更为罕见,目前仅有几例报告,主要发生在胃~([1-4])、胰腺~([5])、肝~([6])和壶腹部~([7])。由于此类肿瘤非常罕见,故容易误诊。有关该肿瘤的病理特征、临床治疗及预后等方面还有待进一步的研究。现报道1例双性癌,结合文献复习对本病的临床病理特征及鉴别诊断进行初步探讨。
Bisexual cancer is a special type of mixed adenoneuroendocrine carcinoma (MANEC), defined as having both glandular epithelial and neuroendocrine differentiation in tumor cells. MANEC is relatively rare, and bisexual cancers are rarer, with only a few reports so far, mainly in the stomach ~ (1-4), pancreas ~ (5), liver ~ (6) and ampulla ~ ([7]). Because of this very rare tumor, it is easy to misdiagnosis. The pathological features of the tumor, clinical treatment and prognosis and other aspects remains to be further studied. We report a case of bisexual cancer, combined with the literature review of the clinical and pathological features of the disease and differential diagnosis of a preliminary study.