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目的探讨环戊硫酮治疗干燥综合征临床疗效及安全性。方法对我院收治的50例干燥综合征患者随机分成治疗组和对照组各25例,分别给予环戊硫酮和维生素C治疗,疗程4周,观察治疗前后两组患者泪液分泌量、唾液分泌量及主观症状。结果治疗组能明显增加唾液流率,液浸湿滤纸的长度明显延长,各主要主观症状明显缓解,较对照组效果明显(P<0.05)。结论环戊硫酮对干燥综合征患者有良好的治疗作用且不良反应小,值得临床推广应用。
Objective To investigate the clinical efficacy and safety of cyclopentanthione in the treatment of Sjogren’s syndrome. Methods Fifty patients with Sjogren’s syndrome admitted to our hospital were randomly divided into treatment group and control group, 25 cases were treated with cyclopentanthione and vitamin C respectively. The course of treatment was 4 weeks. The levels of tear secretion and salivary secretion in both groups were observed before and after treatment Volume and subjective symptoms. Results The treatment group significantly increased the salivary flow rate. The length of the wet-soaked filter paper was significantly prolonged, and the main subjective symptoms were significantly relieved. The effect was more obvious than that of the control group (P <0.05). Conclusions Cyclopentadione has a good therapeutic effect on patients with Sjögren’s syndrome and has a small adverse reaction, which is worthy of clinical application.