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目的观察纤溶酶与尼莫地平联合治疗糖尿病周围神经病变的治疗作用。方法选择糖尿病周围神经病变患者60例,随机分为治疗组(n=30)和对照组(n=30)。对照组应用维生素B1、B12针剂,1次/d,肌肉注射,口服维生素B6、ATP,连用14d为一疗程。治疗组在对照组治疗基础上加用降纤酶、尼莫地平,14d为一疗程。治疗前后分别记录患者临床表现,肌电图,血液流变学的变化。结果治疗组治疗后的总有效率明显高于对照组(P<0.01)。结论纤溶酶与尼莫地平联合治疗糖尿病周围神经病变能显著改善临床症状,疗效肯定,比较安全。
Objective To observe the therapeutic effect of plasmin combined with nimodipine on diabetic peripheral neuropathy. Methods Sixty patients with diabetic peripheral neuropathy were randomly divided into treatment group (n = 30) and control group (n = 30). The control group used vitamin B1, B12 injection, 1 / d, intramuscular injection, oral vitamin B6, ATP, 14d for a course of treatment. The treatment group in the control group based on the use of defibrase, nimodipine, 14d for a course of treatment. Before and after treatment were recorded in patients with clinical manifestations, EMG, hemorheology changes. Results The total effective rate after treatment in the treatment group was significantly higher than that in the control group (P <0.01). Conclusion The combination of plasmin and nimodipine in the treatment of diabetic peripheral neuropathy can significantly improve the clinical symptoms, efficacy is sure, more secure.