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自1913年Fisher首先报导本瘤以来,已历经半世纪余,虽经许多专家研究,但由于本瘤材料来源困难,至今有关其组织发生尚未解决,众说纷云,莫衷一是。近来我们获得一例临床,X线表现、光镜病理均较典型病例,试图通过电镜观察来探讨其组织发生。材料来自一女性、63岁患者,发现右小腿肿物三月余,轻度疼痛,表面皮肤完整,身体它处未找见肿块。X线片(图1)见肿瘤位于胫骨中段髓腔内,呈溶骨性破坏,长轴与骨平行,混有硬化区,部分皮质有锯齿状改变。电镜制样按常规进行,戊二醛、锇酸双固定,618树脂包埋,半薄切片定位,铀铅双重染色,日立H—500型电
Since Fisher first reported the tumor in 1913, it has been more than half a century. Although many experts have studied it, due to the difficulty of the origin of the tumor material, the occurrence of the disease has not been resolved so far. There are many opinions about this issue. Recently, we obtained a case of clinical, X-ray findings, light microscopy pathology are more typical cases, trying to explore its organization by electron microscopy. The material came from a female, 63-year-old patient. He found that the right calf mass was more than three months old. He had mild pain, had a superficial skin, and had no lump in the body. The X-ray film (Fig. 1) showed that the tumor was located in the medullary cavity of the middle humerus. It showed osteolytic destruction. The long axis was parallel to the bone and mixed with a hardened area. Some of the cortex showed jagged changes. Electron microscope sample preparation was performed as usual, glutaraldehyde, tannic acid double fixed, 618 resin embedding, semi-thin section positioning, uranium-lead double staining, Hitachi H-500 type electricity