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目的:比较卵巢功能正常的体外授精胚胎移植治疗患者,应用克罗米芬组合低剂量促性腺激素方案和常规拮抗剂方案的临床治疗结局.方法:应用前瞻性随机对照研究,选择2014年9月-2015年12月在南京医科大学第一附属医院就诊,女方卵巢功能评估正常,拟行体外授精胚胎移植治疗的120对夫妇为研究对象.按随机数字信封法分为实验组(克罗米芬组合低剂量促性腺激素方案)和对照组(常规拮抗剂方案)进行促排卵及体外授精胚胎移植治疗,两组均行全胚冷冻,择期冻融胚胎移植,随访至活产或用完本次取卵周期形成的所有胚胎,比较两组患者治疗的临床指标、实验室指标和临床妊娠结局.结果:实验组患者促性腺激素用量低于对照组、促性腺激素用药天数短于对照组,但两组患者临床妊娠率、活产率的差异无统计学意义.结论:克罗米芬组合低剂量促性腺激素方案,在促性腺激素用量减少和用药天数缩短情况下,能达到常规拮抗剂方案的临床治疗结局,是一种经济、有效、温和的新促排卵方案.“,”Objective:To compare the clinical outcomes of patients with normal ovarian function in vitro fertilization and embryo transfer therapy,using clomiphene citrate combined with low dose gonadotropin regimen and conventional antagonist regimen.Methods:A prospective randomized controlled trial was conducted.One hundrend and tweenty couples were selected from September 2014 to December 2015 at the First Affiliated Hospital of NJMU,the normal ovarian function of the woman and the in vitro fertilization embryo transfer therapy.The women were divided into experimental group (clomiphene citrate combination low dose gonadotropin regimen) and control group (conventional antagonist regimen) according to the randomized digital envelope method.Both of the two groups All embryo were frozen and frozen-thawed embryos were transfered,followed-up to live or running out of all embryos of this cycle in two groups,compare the clinical and laboratory results and clinical outcomes of the two groups were compared.Results:The dosage of gonadotropin in the experimental group was lower than that in the control group.The stimulate time of gonadotropin was shorter than that of the control group.There was no significant difference in clinical pregnancy rate and cumulative live birth rate between two groups.Conclusion:The combination of clomiphene citrate and low dose gonadotropin program can achieve the clinical outcome as good as the conventional antagonist regimen in the case of reduced dosage of gonadotropin and shortened stimulation days.It is a new economical,effective and mild ovulation induction program.