据报道,高龄可使葡萄糖耐量、外周胰岛素抵抗及餐后高胰岛素血症的代谢变化受损。许多实验试图证明高龄者高胰岛素血症产生是否由于增加了胰岛素分泌,减低了胰岛素清除率或二者皆有。在大鼠体内或体外试验结果表明,随着增龄,胰岛素分泌减少;而在人却可见到胰岛素水平增加。有的学者也发现在老年人胰岛素清除率减慢,有的则认为无变化。实验结果不一致的原因在于很难直接测定门脉循环内真正的胰岛素产生速率。外周胰岛素 It has been reported that advanced age impairs metabolic changes in impaired glucose tolerance, peripheral insulin resistance and postprandial hyperinsulinemia. Many experiments have attempted to demonstrate whether elderly hyperinsulinemia is due to increased insulin secretion, reduced insulin clearance, or both. In vivo or in vitro test results in rats show that with aging, insulin secretion decreased; but in humans but can see an increase in insulin levels. Some scholars also found that insulin clearance in the elderly slowed down, while others considered no change. The reason for inconsistent experimental results is that it is difficult to directly determine the true rate of insulin production in the portal circulation. Peripheral insulin