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目的:探讨PHLPP在上皮性卵巢癌的表达及其意义。方法:采用免疫组织化学方法检测40例良性卵巢肿瘤、40例交界性卵巢肿瘤、39例恶性卵巢肿瘤病灶的PHLPP表达情况。结果:PHLPP在良性卵巢肿瘤中高表达,表达率92.5%,在交界性卵巢肿瘤中表达率为75.0%,在卵巢癌中表达率最低为25.6%,各组相比较有统计学差异(2χ=69.090 0,P<0.01)。结论:PHLPP与卵巢癌发生、发展密切相关,为卵巢癌的早期诊断及预防提供了新思路。
Objective: To investigate the expression of PHLPP in epithelial ovarian cancer and its significance. Methods: The expressions of PHLPP in 40 cases of benign ovarian tumor, 40 cases of borderline ovarian tumor and 39 cases of malignant ovarian tumor were detected by immunohistochemistry. Results: PHLPP was overexpressed in benign ovarian tumors, the expression rate was 92.5%, the expression rate was 75.0% in borderline ovarian tumors and the lowest was 25.6% in ovarian carcinomas, with statistical significance (2χ = 69.090 0, P <0.01). Conclusion: PHLPP is closely related to the occurrence and development of ovarian cancer, which provides a new idea for the early diagnosis and prevention of ovarian cancer.