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天然产物退热碱和异退热碱以及类似结构化合物表现出优异的抗疟疾活性,且未见产生耐药性的报道。本文综述了它们的各种不对称合成方法,评价了其优缺点,并简要介绍了其衍生物的合成。
The natural product antipyretic bases and the iso-existant caustic soda and similar structural compounds show excellent anti-malarial activity with no reports of drug resistance. This article reviews their various asymmetric synthesis methods, evaluates their advantages and disadvantages, and briefly describes the synthesis of their derivatives.