论文部分内容阅读
目的:探讨心力衰竭患者血清心肌肌钙蛋白I(cTnI)水平与心脏功能及远期心脏事件的关系。方法:测定66例心力衰竭患者血清cTnI,肌酸激酶同功酶(CK-MB),并分为cTnI正常组和升高组,随访至少12月患者远期心脏事件,分析cTnI与心脏功能及远期心脏事件的关系。结果:66例心力衰竭患者中有27例血清cTnI升高,5例CK-MB轻度升高;Ⅲ级心功患者cTnI升高检出率(66.7％)比Ⅱ级心功cTnI升高检出率(5.9％),显著增高(P<0.05);Ⅳ级心功患者cT-nI升高检出率(100％)比Ⅲ级心功患者明显增高(P<0.05)。62例心力衰竭患者远期随访,随访时间(18±6)个月,cTnI正常组远期心脏事件17例次,cTnI升高组远期心脏事件35例次(P<0.01)。结论:心功能越差cTnI升高的检出率越大,血清cTnI不仅是心力衰竭患者心肌损伤的敏感标志物,而且是远期心脏事件的独立预测因子。
Objective: To investigate the relationship between serum cardiac troponin I (cTnI) levels and cardiac function and long-term cardiac events in patients with heart failure. Methods: Serum cTnI and creatine kinase isoenzyme (CK-MB) were determined in 66 patients with heart failure and divided into normal and elevated cTnI groups. The long-term cardiac events were followed up for at least 12 months. The correlations between cTnI and cardiac function and Long-term cardiac events. Results: Serum cTnI was elevated in 27 of 66 patients with chronic heart failure, and CK-MB was slightly elevated in 5 patients. The positive rate of cTnI in patients with grade Ⅲ heart failure (66.7%) was higher than that of grade Ⅱ cTnI The positive rate of cT-nI in patients with grade Ⅳ heart failure (100%) was significantly higher than that of grade Ⅲ patients with heart failure (5.9%) (P <0.05). Sixty-two patients with long-term follow-up of heart failure were followed up for 18 ± 6 months. Long-term cardiac events in cTnI-normal group were 17 cases and long-term cTnI-induced cardiac events were 35 cases (P <0.01). Conclusion: The higher the detection rate of cTnI, the worse the cardiac function, the serum cTnI is not only a sensitive marker of myocardial injury in patients with heart failure, but also an independent predictor of long-term cardiac events.