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分别以40、120、360mg/kg氯化锂水溶液经口染毒小鼠,观察染毒孕鼠胎仔外观、内脏及骨骼的改变.结果表明:(1)胎仔外观以体表出现血肿为主,120mg/kg组发生率为37.80%,明显高于对照组(P<0.01).尚发现无脑、缺趾、脊柱裂等畸形;(2)内脏检查见360mg/kg组腭裂及40mg/kg组肾脏畸形,发生率分别为3.53% 和5.56%;(3)骨骼检查见新的畸形类型;胸骨异常和跗骨缺失.由此提示:不同剂量的氯化锂可通过母体胎盘对胎仔产生不同程度的致畸作用.
The mice were challenged with 40, 120 and 360 mg / kg lithium chloride solution respectively to observe the appearance, visceral and skeletal changes of fetus in pregnant rats.The results showed that: (1) 120mg / kg group was 37.80%, which was significantly higher than that of the control group (P <0.01) .No malformations such as brain, missing toe and spina bifida were found. (2) Visceral examination revealed 360mg / kg cleft palate and 40mg / kg group Kidney deformity, the incidence rates were 3.53% and 5.56% respectively; (3) The new type of deformity was found in skeletal examination; sternal anomaly and tarsal absence .Therefore, different doses of lithium chloride could produce different degrees of fetal Teratogenic effect.