目的　探讨系统性红斑狼疮（ＳＬＥ） 患者中Ｔｈ２ 型细胞因子ｍ ＲＮＡ 的表达。方法　用逆转录多聚酶链反应（ ＲＴＰＣＲ） 法检测了１０ 例正常人和１５ 例活动期ＳＬＥ 患者外周血单个核细胞（ＰＢＭＣ） 中白介素６（ＩＬ６） 和白介素１０（ＩＬ１０） ｍ ＲＮＡ 表达的水平。结果　与正常人相比，活动期ＳＬＥ 患者ＰＢＭＣ 中ＩＬ６ 和ＩＬ１０ ｍ ＲＮＡ 的表达水平均增高（ 均 Ｐ＜ ０ ．０１） 。结论　ＳＬＥ 患者中Ｔｈ２ 型细胞因子ＩＬ６ ＩＬ１０ 的表达上调，可能在发病机制中起一定作用。 Objective To investigate the expression of Th2 cytokine m RNA in patients with systemic lupus erythematosus (SLE). Methods The levels of interleukin 6 (IL6) and interleukin 10 (IL10) in peripheral blood mononuclear cells (PBMCs) from 10 normal controls and 15 active SLE patients were detected by reverse transcription-polymerase chain reaction (RTPCR) ) M RNA expression level. Results Compared with normal controls, the expression levels of IL6 and IL10 m RNA in PBMC of patients with active SLE increased (all P <0.01). Conclusion SLE patients with Th2-type cytokines IL 6 IL-10 expression may play a role in the pathogenesis.