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近年来医学免疫学进展很快。以 AIDS 等为代表的免疫异常病人的增加给麻醉科学提出了新问题,即要求医生能随时掌握并处置病人术中的免疫功能变化.以前,作者曾通过多种方法证明并报道了麻醉和手术对机体免疫功能的抑制作用。最近,由于细胞融合方法的改进,很容易制备出能分泌单克隆抗体的淋巴细胞杂交瘤。有鉴于此,作者应用抗人淋巴细胞膜抗原的单克隆抗体,探讨了病人术中及术后一段时同内机体的免疫及内分泌功能的变化。作者同时应用两种单抗,以值双标记染色法观察了外周血 T 淋巴细胞亚群
In recent years, medical immunology has progressed rapidly. The increase in immunocompromised patients represented by AIDS etc. poses a new problem for the science of anesthesiology, which requires doctors to be able to grasp and dispose of changes in the patient’s immune function at any time. Previously, the author had demonstrated and reported anesthesia and surgery through various methods. Inhibition of the body’s immune function. Recently, due to improvements in cell fusion methods, lymphoma hybridomas that secrete monoclonal antibodies can be easily prepared. In view of this, the authors applied monoclonal antibodies against human lymphocyte membrane antigens to investigate changes in the immune and endocrine functions of the same body during and after surgery. The authors also used two kinds of monoclonal antibodies to observe peripheral blood T lymphocyte subsets by dual-labeled staining